Sunday, 8 October 2017

Evidence for use of Stiripentol and other agents to effectively inhibit cancer stem-like cell activity.

A few months ago (in March, in a previous post in my blog), I theorised that stiripentol (the 'ketogenic diet pill') may be of use as an anti-cancer agent for brain cancer and perhaps others due to inhibition of Lactate Dehydrogenase activity. I think I have just found recent evidence that this theory may be valid.
Stiripentol

Stiripentol by Diatomit enhances beneficial effects of therapeutic ketosis for cancer management by inhibiting lactate dehydrogenase and offers neuroprotection and increased seizure threshold by enhancing central GABA neurotransmission.
Here is an extra from the paper with reference to stiripentol and complimentary agents that could possibly offer a safe, synergistic therapeutic benefit.
'We have now identified a variety of clinically-approved drugs (stiripentol), natural products (caffein acid phenyl ester (CAPE), ascorbic acid, silibinin) and experimental pharmaceuticals (actinonin, FK866, 2-DG), that can be used to effectively inhibit cancer stem-like cell activity.'
The study can be found here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400535/

11 comments:

  1. Hi Andrew, delighted to have found your site via Andy Duff and look forward to following your adventures...my husband has been following a ketogenic diet after DX of glioblastoma. Feeling very well (though we don't currently know what 'the carbuncle' is doing as he was basically sent home to die with some steroids to control inflammation. Fascinated to read all your work. Best, Kate Everett

    ReplyDelete
    Replies
    1. Hi Kate,

      Thanks for getting in touch. Has he tried Boswellia Serratta for the brain swelling?

      Andrew

      Delete
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      Delete
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      Delete
  2. Hi Andrew. How did you get over your problem with salicylates? Thanks. Kate

    ReplyDelete
    Replies
    1. sensitivity has improved over time as my brain has healed but I am still quite sensitive to it.

      Delete
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  6. I am here to testify on how I was healed from my CANCER DISEASE by DR. ogbela the great herbalist,
    I was having a serious headache though I take treatments the headache never goes off, I was told
    to go for check-up, I did the result was that I am having the CANCER of the brain, that there is
    tumor in my brain, I was not myself ever since that day, everything went
    worse day by day, I was hoping for death, I was told about a great spell caster who can heal any disease in this life, I collected his email which is drogbelaherbalhome@gmail.com or whatsap +2348136354191 quickly I emailed him to see if my disease can be healed, \he told me that I am at the right place, that I should not bother that everything will be fine, I believed him base on the testimonies I had seen on the internet, he asked me to buy some items which I bought, he cast the spell and told me that there is a herbs medicine that he will prepare and send to me through courier service, my parcel arrived I took the herbs medicine as prescribed by him, I started
    feeling normal, the headache was gone, he asked to go for check-up, the tumor that was seen in my brain was no more. he also help my friend to cure his KIDNEY DISEASES after i was cure i also introduce my friend to
    this great man and now my friend is also cure I thank DR. ogbela, if you are having serious problem you can contact him via his email which is drogbelaherbalhome@gmail.com or whatsapp his mobile line on +2348136354191. contact him and also view his blogspot: drogbelaherbalhome.blogspot.com

    ReplyDelete
  7. May God bless this wonderful Dr Akuna for what he has done for me, 7 years ago i met with a unknown stranger we met in the club we had fun and i went drunk and we had unprotected sex, i never knew this man had HIV AIDS. 4 month later i was having headache and scratches and fever and always getting sick, it was not easy for me, but i thank God for directing my footsteps to Dr Akuna, he gave me instructions and i followed and in 2 weeks i was completely cured after testing my statue i was HIV AIDS NEGATIVE. Contact Dr Akuna for more information. Email: drakunasolutiontemple@gmail.com or CALL/WHATAPP HIM:+2347154625070 or visit web: https://drakunasolutiontempleofallkindsofsicknessistreated.wordpress.com/2017/12/08/about-me/ or visit:http://drakunasolutiontempleofallcureandspell.website2.me/contact

    ReplyDelete